Surgery Dosing Calculator
This unique HUMATE-P Surgery Dosing Calculator makes individual dosing fast, easy, and convenient. The calculator determines the correct HUMATE-P loading dose (measured in VWF:RCo units) needed to achieve the desired increase in circulating VWF, as defined in the product prescribing information. (For guidance on loading dose recommendations, please refer to Table 3 of the full prescribing information). All subsequent doses should be based on patient response and measured levels of VWF:RCo and FVIII.
These calculations are to be used only with HUMATE-P and are applicable for VWF:RCo loading dose calculations for the prevention of excessive bleeding during and after surgery for all types of VWD.
Calculate the Correct HUMATE-P Loading Dose
Instructions: To determine the HUMATE-P loading dose (as measured in VWF:RCo units) needed to achieve the target increase in circulating VWF:
- Enter the patient's body weight (BW) in kilograms (kg) OR pounds (lb)
- Enter the patient's baseline level (BL) of VWF:RCo (measured as IU VWF:RCo/dL)
- Enter the patient's target level (TL) of VWF:RCo (measured as IU VWF:RCo/dL)
- Enter the patient's in vivo recovery (IVR). IVR is measured as rise in IU/dL per IU/kg administered. If unknown, please click on the link next to the IVR field and a value of 2 IU/dL will be used as the default per the dosage instructions in the product prescribing information.
A full chart of the HUMATE-P Surgery Dosing Calculator for VWD is also available. General Rule: Doses are calculated based on an expected in vivo recovery of 2.0 IU/dL rise in VWF:RCo activity per every IU/kg of VWF:RCo administered.