[TL (IU/dL) - BL (IU/dL)] x BW (kg)
IVR(IU/dL)/(IU/kg)
HUMATE-P simplifies dosing
for convenient VWD therapy
HUMATE-P
simplifies dosing
for convenient VWD therapy
The average VWF:RCo to FVIII ratio is 2.4 to 1
HUMATE-P can successfully achieve therapeutic levels of VWF without raising FVIII to supernormal levels.
HUMATE-P is approved to treat bleeding episodes and to prevent excessive bleeding during and after surgery.
For bleeding episodes, administer 40–80 IU VWF:RCo per kg body weight every 8–12 hours
Surgical dosing differs by type of surgery (i.e., major, minor) and should be customized to patient need according to baseline and target levels of VWF:RCo and FVIII. Our Surgical Dosing Calculator simplifies individualized therapy for surgery patients
In emergency surgery situations, administer a loading dose of 50 to 60 International Units (IU) VWF:RCo/kg body weight and, subsequently, closely monitor the patient’s trough coagulation factor levels
Please see Dosage and Administration in the full Prescribing Information
Calculate the correct
HUMATE-P loading dose
Make individualized HUMATE-P dosing fast, easy, and convenient
This calculator determines the correct HUMATE-P loading dose (measured in VWF:RCo units) needed to achieve the desired increase in circulating VWF, as defined in the product prescribing information. (For guidance on loading dose recommendations, please refer to Table 3 of the full prescribing information). All subsequent doses should be based on patient response and measured levels of VWF:RCo and FVIII.
These calculations are to be used only with HUMATE-P and are applicable for VWF:RCo loading dose calculations for preventing excessive bleeding during and after surgery for all types of VWD.
Dosage Formula
= VWF:RCo units required
Dosage Calculation Example
[100 (IU/dL) - 44 (IU/dL)] x 85 (kg)
2.0 (IU/dL)/(IU/kg)
= 2380 VWF:RCo units required
VWF:RCo and FVIII content identified and labeled for prescribing precision
HUMATE-P has a high VWF:FVIII ratio to achieve therapeutic levels of VWF without raising FVIII to supernormal levels.
HUMATE-P is available in a range of vial sizes for convenient dosing, transportation, and storage
VWF:RCo/vial |
FVIII/vial |
Diluent |
NDC number |
|---|---|---|---|
600 IU |
250 IU |
5 mL |
63833-615-02 |
1200 IU |
500 IU |
10 mL |
63833-616-02 |
2400 IU |
1000 IU |
15 mL |
63833-617-02 |
Help your patients learn to self-infuse HUMATE-P
Learning to self-infuse HUMATE-P can help your patients manage their bleeding disorder better. Please take a few moments to watch the video, and soon you will be able to assist your patients with self-infusion. The video below demonstrates the 6 simple steps to self-infuse HUMATE-P using the Mix2Vial® device.
Mix2Vial® simplifies HUMATE-P reconstitution
For healthcare professionals and patients, the Mix2Vial is efficient and convenient.
The Mix2Vial device:
- Can help prevent needle-stick injuries
- May shorten preparation time for HUMATE-P infusions
- Includes a built-in filter
View a video demonstration on how to self-infuse with HUMATE-P using the Mix2Vial.
Instructions for reconstituting HUMATE-P using Mix2Vial®
HUMATE-P should be prepared and administered at room temperature using aseptic technique.
For reconstitution, be sure to use:
Either the Mix2Vial filter transfer set provided with HUMATE-P or a commercially available double-ended needle and vented filter spike
Plastic disposable syringes (protein solutions like HUMATE-P tend to adhere to the ground glass surface of all-glass syringes)
Step 1 OF 12
Ensure that the HUMATE-P vial and diluent vial are at room temperature.
UP TO 25ºc [77ºf]
Step 2 OF 12
Place the HUMATE-P vial, diluent vial, and Mix2Vial transfer set on a flat surface.
Step 3 OF 12
Remove the HUMATE-P and diluent vial flip caps. Wipe the stoppers with an alcohol swab. Allow the stoppers to dry prior to opening the Mix2Vial transfer set package.
Step 4 OF 12
Open the Mix2Vial transfer set package by peeling away the lid. Leave the Mix2Vial transfer set in the clear package.
Step 5 OF 12
Place the diluent vial on a flat surface and hold the vial tightly. Grip the Mix2Vial transfer set together with the clear package and push the plastic spike at the blue end of the Mix2Vial transfer set firmly through the center of the stopper of the diluent vial.
Step 6 OF 12
Carefully remove the clear package from the Mix2Vial transfer set. Make sure that you pull up only the clear package and not the Mix2Vial transfer set.
Step 7 OF 12
With the HUMATE-P vial placed firmly on a flat surface, invert the diluent vial with the Mix2Vial transfer set attached and push the plastic spike of the transparent adapter firmly through the center of the stopper of the HUMATE-P vial. The diluent will automatically transfer into the HUMATE-P vial.
Step 8 OF 12
With the diluent and HUMATE-P vial still attached to the Mix2Vial transfer set, gently swirl the HUMATE-P vial to ensure the HUMATE-P is fully dissolved. Do not shake the vial.
Step 9 OF 12
With one hand, grasp the HUMATE-P side of the Mix2Vial transfer set, and with the other hand grasp the blue diluent-side of the Mix2Vial transfer set. Then, unscrew the set into two pieces.
Step 10 OF 12
Draw air into an empty, sterile syringe. While the HUMATE-P vial is upright, screw the syringe to the Mix2Vial transfer set. Inject air into the HUMATE-P vial. While keeping the syringe plunger pressed, invert the system upside down and draw the concentrate into the syringe by pulling the plunger back slowly.
Step 11 OF 12
Now that the concentrate has been transferred into the syringe, firmly grasp the barrel of the syringe (keeping the syringe plunger facing down) and unscrew the syringe from the Mix2Vial transfer set. Attach the syringe to a suitable intravenous administration set.
Step 12 OF 12
If patient requires more than one vial, pool the contents of multiple vials into one syringe. Use a separate unused Mix2Vial for each product vial.
For additional information, please see full Prescribing Information
Room temperature storage fits your needs
When stored at room temperature (up to 25°C [77°F]), HUMATE-P is stable for 36 months up to the expiration date on its label. Do not freeze.
