Glossary of Terms

Clot: A fibrin and platelet “plug” or “seal” that stops the bleeding after you’re cut or bruised.

Clotting: The process that causes clots to form. Doctors call it hemostasis.

Factor VIII (FVIII): A protein factor that plays an important part in the clotting process. FVIII works with VWF to help your body build stable clots.

Hematologist: A doctor who specializes in bleeding disorders.

Hereditary: Passed down through genes, from parents to children.

Menorrhagia: Heavy or prolonged menstrual periods.

Protein factors: Specific proteins in your blood that start and control the clotting process.

von Willebrand disease (VWD): A bleeding disorder that occurs when your body isn’t producing enough VWF, or when the existing VWF in your body isn’t functioning properly.

von Willebrand factor (VWF): A protein factor that plays an important role in your body’s clotting process. VWF helps platelets bind together and stabilizes FVIII.

VWF/FVIII replacement therapy: A type of VWD treatment (such as Humate-P) that provides concentrated VWF to supplement or replace the VWF that is missing from your body.


Important Safety Information

Antihemophilic Factor/von Willebrand Factor Complex (Human), Humate-P® is approved to treat and prevent bleeding in adult patients with hemophilia A (classical hemophilia). Humate-P also treats spontaneous or trauma-induced bleeding episodes in adults and children with von Willebrand disease (VWD) and prevents excessive bleeding during and after surgery in patients with mild, moderate or severe VWD. Humate-P is not known to prevent spontaneous bleeding episodes.

Do not take Humate-P if you have had extreme sensitivity or an allergic response to antihemophilic or von Willebrand factor preparations. Your doctor will monitor you for events related to abnormal blood clotting.

Humate-P is made from human blood and could contain infectious agents. The risk that these agents may transmit disease cannot be completely eliminated, but has been reduced by screening plasma donors and testing donated plasma for certain viruses, and by inactivating and/or removing viruses during manufacturing.

In studies, more than 5% of patients reported the following adverse reactions to Humate-P: allergic/anaphylactic reactions, including hives, chest tightness, rash, itching, and swelling. The most common adverse reactions after surgery were bleeding at the wound or infusion site, and nosebleeds.

Please see full prescribing information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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© CSL Behring 2019. The product information on this site is intended for US residents only. HUM / 10-11-0010(1) 8/2015