Humate-P Dosing Calculator for von Willebrand Disease
Dosing Calculator (Application)
The new, improved Humate-P dosing calculator is here, making individual dosing
fast, easy and convenient. CSL Behring provides healthcare providers (HCPs) with
yet another innovative tool to improve patient care. This dosing calculator application
makes accurate dosing of Humate-P even more convenient by allowing HCPs to calculate
the dosing needed for patients with von Willebrand disease. The application
can calculate dosages for a variety of patient needs, including emergency surgery,
perioperative and postoperative surgery, and for bleeding episodes.
Available for download
The new dosing calculator can be downloaded to your iPhone®, iPad®, Android
or BlackBerry®. Just click the appropriate link below:
To download the latest Humate-P dosage calculator, copy the following link into
the web browser of your BlackBerry device:
http://www.humate-p.com/mobile/BlackBerryDosageCalculator
Were sorry. The Humate-P Dosage Calculator currently requires the
Operating System of your BlackBerry device to be version 4.6 or greater.
Surgery Dosing Calculator
This unique Humate-P Surgery Dosing Calculator makes individual dosing fast, easy,
and convenient. The calculator determines the correct Humate-P loading dose
(measured in VWF:RCo units) needed to achieve the desired increase in circulating
VWF, as defined in the product prescribing information. (For guidance on loading
dose recommendations, please refer to Table 3 of the
full prescribing Information). All subsequent doses should be based on patient
response and measured levels of VWF:RCo and FVIII.
These calculations are to be used only with Humate-P and are applicable for VWF:RCo
loading dose calculations for the prevention of excessive bleeding during and after
surgery for all types of VWD.
Calculator for Loading Dose for Humate-P
Instructions: To determine the Humate-P loading dose (as measured in VWF:RCo
units) needed to achieve the target increase in circulating VWF:
- Enter the patient's body weight (BW) in kilograms (kg) OR pounds (lb)
- Enter the patient's baseline level (BL) of VWF:RCo (measured as IU VWF:RCo/dL)
- Enter the patient's target level (TL) of VWF:RCo (measured as IU VWF:RCo/dL)
- Enter the patient's in vivo recovery (IVR). IVR is measured as rise in IU/dL per
IU/kg administered. If unknown, please click on the link next to the IVR field and
a value of 2 IU/dL will be used as the default per the dosage instructions in the
product prescribing information.
Important Safety Information
Antihemophilic Factor/von Willebrand Factor Complex (Human), Humate-P® is approved to treat and prevent bleeding in adult patients with hemophilia A (classical hemophilia). Humate-P also treats spontaneous or trauma-induced bleeding episodes in adults and children with von Willebrand disease (VWD) and prevents excessive bleeding during and after surgery in patients with mild, moderate or severe VWD. Humate-P is not known to prevent spontaneous bleeding episodes.
Do not take Humate-P if you have had extreme sensitivity or an allergic response to antihemophilic or von Willebrand factor preparations. Your doctor will monitor you for events related to abnormal blood clotting.
Humate-P is made from human blood and could contain infectious agents. The risk that these agents may transmit disease cannot be completely eliminated, but has been reduced by screening plasma donors and testing donated plasma for certain viruses, and by inactivating and/or removing viruses during manufacturing.
In studies, more than 5% of patients reported the following adverse reactions to Humate-P: allergic/anaphylactic reactions, including hives, chest tightness, rash, itching, and swelling. The most common adverse reactions after surgery were bleeding at the wound or infusion site, and nosebleeds.
Please see full prescribing information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
The information provided here is primarily intended for use by physicians and other healthcare professionals in the United States. The CSL Behring product listed may not have been approved in other countries and may not be available everywhere.